Entha Manchivaadavura is the story of a man named Balu (Kalyan Ram).

Born on the same day and at the same time, Varsha and Mahi are connected to each other by destiny but when a situation threatens to separate them, they meet each other again in Hyderabad.

Raghu Ramayya (Satyaraj) is a man in his 70s and gets diagnosed with lung cancer.

An extremely talented DJ who works at a local night club gets himself in an adventure where he must fight all odds to survive.

Abhilash aka Abhi (Atharva) is an aspiring film director who has a great passion for film making. He gets insulted by a senior film director on the sets, where he degrades Abhi and questions his worth.

Pencil Parthasarathi (Nani) makes ends meet for his survival by converting Popular Hollywood crime movies into local Telugu novels.

Samba Siva Rao/Sam (Nagarjuna) is a middle-aged man who loves staying a Bachelor.

Sai Sreenivas Athreya, a clever detective from Nellore, encounters trouble while he investigates the case of an anonymous body spotted nearby a railway route.

Poorna (Naga Chaitanya) lives a middle-class life with his father (Rao Ramesh). He always wanted to make it to the Indian cricket team and his first goal was to earn a place in the railway cricket team.