Spencer hides the pieces of the Jumanji video game, repairs the gaming system in his basement and gets sucked into the universe. Spencer's friends Bethany, Fridge, and Martha arrive to see Spencer missing along with the game being open and decide to re-enter Jumanji to save him. They witness the unexpected changes and move through the terrains of the most dangerous game in the world.

After the devastating events of Avengers: Infinity War (2018), the universe is in ruins. With the help of remaining allies, the Avengers assemble once more in order to reverse Thanos' actions and restore balance to the universe.