NTR Mahanayakudu is the sequel to the first film that depicted the life of the veteran actor, Nandamuri Taraka Rama Rao (Balakrishna) on the big screen.

A biographical film based on the 900-mile padayatra of Y. S. Rajasekhara Reddy, who served as Chief Minister of Andhra Pradesh from 2004 to June 2009 representing Indian National Congress.

Venky (Venkatesh) is an orphan and works as an assistant for a politician (Raghu Babu). Through a marriage bureau, he gets a match - Harika (Tamannah).

Four orphan kids witness child trafficking crime when they pass by a railway track.