Karthik (Karthikeya) is an NRI who has no emotions and family attachments. As promised to his father, he visits India and during his visit, he falls for a girl called Anjali (Simrat Kaur). Who is this Anjali? What kind of changes does she bring in Karthik's life? Will Karthik change his mindset? Answers to all these questions form the rest of the story of Prematho Mee Karthik.