Kalpana is a horror flick, which revolves around the life of a mangalmukhi (transgender) played by Sai Kumar, who finds herself as the odd person out in every situation. Her story is retold by Raghava (Upendra), who becomes the vehicle for Kalpana’s unfulfilled desires. The film also stars Lakshmi Rai as Priya and Babu Antony as Bhai.