Eduruleni Manishi is the story of Surya Murthy (Nagarjuna), head of a village who is highly respected by everyone. He gets married to Vasundhara (Soundarya) only to realise later that she married him to take revenge. What is the reason behind Vasundhara's motives and how does Satya Murthy get to the bottom of the issue is the rest of the story.