In an attempt to protect the world from Annabelle, Demonologists Ed and Lorraine Warren bring the possessed doll into their home and trap her spirit in a sacred glass and enlist the blessing of the holy priest. Unaware of the dangers created by the Annabelle doll, two teenage babysitters and the ten-year-old daughter of Ed and Lorraine Warren become the new target of this demonic spirit.

In 1973 Los Angeles, social worker Anna Tate-Garcia ignores the eerie warning of a troubled mother suspected of child endangerment. Anna and her own small kids are soon drawn into a frightening supernatural realm where they are stalked by the terrifying La Llorona from the legend. Their only hope to survive La Llorona's deadly wrath may be a disillusioned priest and the mysticism he practices to keep evil at bay, on the fringes where fear and faith collide.