Arjun Reddy (Vijay Deverakonda) is a Surgeon and the topper of the college. He falls in love with his junior, a Tulu girl (Shalini), who is four years younger to him. Due to some unfortunate incidents, they break up. How life takes them forward forms the rest of the story.

Ave Kallu is the story of hunt of a serial killer. Susi (Kanchana) comes home to realize that her family members are being murdered one after the other. A half-smoked cigarette at every murder scene is her only clue. Bhaskar (Krishna) who is in love with Susi investigates the murder mystery and identifies the killer which leaves everyone in a state of shock.

Abhimanyu (Shoban Babu), the skilled and courageous son of Arjuna (Kantha Rao) learns how to penetrate the impenetrable Padmavyuha (Lotus Formation) in war but doesn't know how to get out of it. He falls for Uttara (Kanchana), daughter of King Virata and marries her with the help of Lord Krishna (N. T. Rama Rao). At war, he has to face the Padmavyuha where the Kauravas await with a dark plan.