Twenty-seven years later, the Losers Club have grown up and gone their separate ways, until a devastating phone call brings them back.

In an attempt to protect the world from Annabelle, Demonologists Ed and Lorraine Warren bring the possessed doll into their home and trap her spirit in a sacred glass and enlist the blessing of the holy priest. Unaware of the dangers created by the Annabelle doll, two teenage babysitters and the ten-year-old daughter of Ed and Lorraine Warren become the new target of this demonic spirit.

In 1973 Los Angeles, social worker Anna Tate-Garcia ignores the eerie warning of a troubled mother suspected of child endangerment. Anna and her own small kids are soon drawn into a frightening supernatural realm where they are stalked by the terrifying La Llorona from the legend. Their only hope to survive La Llorona's deadly wrath may be a disillusioned priest and the mysticism he practices to keep evil at bay, on the fringes where fear and faith collide.