Twenty-seven years later, the Losers Club have grown up and gone their separate ways, until a devastating phone call brings them back.

Legendary half-demon superhero Hellboy is called to the English countryside to battle a trio of rampaging giants. There he discovers The Blood Queen, Nimue, a resurrected ancient sorceress thirsting to avenge a past betrayal. Suddenly caught in a clash between the supernatural and the human, Hellboy is now hell-bent on stopping Nimue without triggering the end of the world.