Ee Cinema Superhit Guarantee is a tragic story of Nani (HM Mahadev) who always falls in love and end up with heartbreak. What is Nani's problem and why does he break up with everyone? The rest of the story forms the crux.

Kanya Reddy (Ajay), the main charged in several murder cases. Bonku Bommareddy (Posani) is a politician, Kanya Reddy's brother. Sharath (Sivaji) kidnaps Kanya Reddy for his sister's revenge and thus begins the story? What's the rivalry between Sarath and Kanya? Why does Sarath want to punish Kanya? What happened to CI Sastri (Bharath) and his brother who are in duty to trace Kanya?