Raghu (Karthik) belongs to a poor Hindu family. His mother teaches music to make a living. Karuna (Aruna), the sister of a rich, influential Christian man returns home a year after pursuing her education in the city. Karuna starts learning music from Raghu's mother. Gradually, Raghu and Karuna fall in love. How the lovers unite braving all the obstacles forms the plot of Seethakoka Chilaka