Mugguru Monagallu is a unique concept comedy entertainer film that revolves around the lives of three disabled people. The first man is blind, the second is deaf while the third one is dumb. They end up developing a budding friendship while they come across a complicated case of serial murders in Hyderabad. How they got involved and how they ended up helping the cops form the gist of this film.

An extremely talented DJ who works at a local night club gets himself in an adventure where he must fight all odds to survive.